The midfielder has been plagued by numerous injuries in recent weeks.
Suffering from a shoulder injury after a bad fall during the match against Nottingham Forest in September, Odegaard suffered yet another setback this Saturday.
At home to West Ham, the Gunners' number eight suffered a knee injury around the 20th minute.
He decided to continue playing, but ultimately realised he couldn't continue and instead made way for Martin Zubimendi.
Read more: Rice and Saka on target for Arsenal as horror show continues for the Hammers
The injury threatens to be a heavy blow for both Arsenal and Norway.