16:08 CET - Sinner's defeat brings an end to his remarkable 30-match winning run on Tour, and blows open the rest of the men's draw, with two-time former champion Carlos Alcaraz also absent.
Can Novak Djokovic capitalise and claim a 25th Grand Slam title? Can two-time former finalist Casper Ruud secure a maiden major? Or will Alexander Zverev finally break his duck on the big stage?
15:47 CET - Red-hot favourite Jannik Sinner is out of the French Open after a shock five-set defeat to world number 56 Juan Manuel Cerundolo!
Having led 6-3, 6-2, 5-1 and cruising to a comfortable win, Sinner's body dramatically gave up on him in the searing Parisian heat, as Cerundolo won six straight games to snatch the third set.
The Argentine showed no signs of easing off against his ailing opponent, and was dominant in sets four and five, prevailing 3-6, 2-6, 7-5, 6-1, 6-1 to secure a maiden top-10 victory and the biggest scalp of his career.
As for Sinner, his hopes of completing a Career Grand Slam will have to wait after a damaging defeat.
15:14 CET - Wow. Men's top seed and heavy favourite for the title, Jannik Sinner, is in serious trouble of going out of the French Open, with Juan Manuel Cerundolo taking the fourth set 6-1 in 36 minutes on Philippe-Chatrier.
Sinner can barely move out on court, as his body cramps in the stifling heat. Is there any way back for the Italian in the deciding set? Keep track of every point right here.
15:00 CET - An absolutely massive story is brewing on Court Philippe-Chatrier, with men's world number one Jannik Sinner in all sorts of trouble in the heat against Juan Manuel Cerundolo.
The Italian was leading by two sets and 5-1 just an hour ago, but his body has completely given up on him, with Cerundolo winning six straight games to take the third 7-5.
Follow every point of the fourth set here!
13:35 CET - On the men's side of the tournament in Paris, talented Italian Flavio Cobolli has cruised to a relatively routine 6-4, 6-4, 6-4 victory against China's Yibing Wu.
The 10th seed won an impressive 82% of points behind his first delivery, setting up a third-round meeting with either Learner Tien or Facundo Diaz Acosta.
Check out all the match stats here.
13:23 CET - Naomi Osaka has progressed to the third round at Roland Garros for the fourth time in her career after a hard-fought 7-6(1), 6-4 triumph over Donna Vekic.
The 16th seed, who has always struggled to find her best form on the surface, saved seven of 10 break-point opportunities against her Croatian opponent, and will face Iva Jovic next.
Elsewhere, Ukraine's Oleksandra Oliynykova is also through after a topsy-turvy 6-3, 0-6, 7-6(5) victory against Kimberly Birrell of Australia.
12:39 CET - Rising star Iva Jovic has produced a stunning performance to reach the third round, with the 17th-seeded American dismantling compatriot Emma Navarro 6-0, 6-3 in just 79 minutes.
Jovic, who struck 18 winners and converted 76% of points behind her first serve against the recent Strasbourg champion, will face either Naomi Osaka or Donna Vekic for a place in the last 16.
Catch up on all the match stats here.
11:02 CET - Play is due to get underway in a few minutes in the French capital, with a host of intriguing second-round matches to look out for this morning!
Donna Vekic vs Naomi Osaka (16)
Facundo Diaz Acosta vs Learner Tien (18)
Iva Jovic (17) vs Emma Navarro
Follow Sinner vs Cerundolo from 12:00 CET
09:10 CET - Good morning and welcome to our coverage of the French Open, as we look ahead to a jam-packed day of tennis in Paris!
We’re just under a couple of hours away from play getting started at Roland Garros, with Naomi Osaka facing Donna Vekic, before men's world number one Jannik Sinner opens proceedings on Court Philippe-Chatrier against Juan Manuel Cerundolo.
Over on Suzanne-Lenglen, women's sixth seed Amanda Anisimova takes on Julia Grabher, while defending champion Coco Gauff continues her pursuit of back-to-back French Open titles against Egypt's Mayar Sherif.
Later on, Aryna Sabalenka faces home favourite Elsa Jacquemot, while the night session match on Philippe-Chatrier sees Matteo Berrettini come up against Frenchman Arthur Rinderknech.
Elsewhere, Ben Shelton, Felix Auger-Aliassime, Madison Keys and Victoria Mboko are also involved on a busy day of second-round matches.