She was joined in exiting Roland Garros by fellow former major winners Emma Raducanu and Sofia Kenin, who both lost their respective opening matches.
Ukrainian Marta Kostyuk earned her 12th consecutive win on clay as she eased past Oksana Selekhmeteva, who was born in Russia but obtained Spanish nationality four days ago, 6-2, 6-3.
The Madrid Open champion then revealed that her family home in Kyiv was nearly struck by a Russian missile during a massive bombardment of the Ukrainian capital earlier on Sunday.
"This morning, 100 metres from my parents' house, a missile fell," the 15th seed said on court.
"I'm obviously very happy to be in the second round. All my thoughts and all my heart were with the people of Ukraine today. My biggest example are Ukrainian people today."
Kostyuk will meet Katie Volynets in the round of 64, after the American beat France's Clara Burel in straight sets.
Swiss 11th seed Belinda Bencic opened play on Court Philippe Chatrier with a 6-2, 6-3 victory over Austrian qualifier Sinja Kraus.
Last year's junior winner, Lilli Tagger, was downed in her debut match in the senior draw at Roland Garros as the Austrian 18-year-old lost 6-3, 3-6, 6-4 to Chinese 32nd seed Wang Xinyu.
Russian teenager and eighth seed Mirra Andreeva navigated her way past 181st-ranked Fiona Ferro of France in straight sets.