Culpepper, who was called up for the game, pulled the Twins within one in the top of the fourth inning with a dinger off Shane Drohan.
Minnesota eventually tied it up 4-4 with an Austin Martin RBI double.
Culpepper, 23, was selected 21st overall by the Twins in the 2024 MLB Draft and wasted no time getting to the MLB level.
After hitting. 289 with 20 home runs and 24 stolen bases in High-A and Double-A ball in 2025, the young infielder was slashing .271/.367/.478 with 14 home runs, 46 RBI, and 17 stolen bases in Triple-A this season before being called up.
Despite going into Friday's game 57-59, the Twins were just three games back of the Chicago White Sox for the American League Central division lead as the season enters its final two months.