Arsenal left back Myles Lewis-Skelly and Newcastle United defender Dan Burn will make their England debuts on Friday against Albania at Wembley in their first 2026 World Cup qualifier.
Manchester United forward Marcus Rashford, currently on loan at Aston Villa, returns to the team as manager Thomas Tuchel named his first starting lineup.
England were drawn in Group K with Albania, Andorra, Latvia and Serbia.
Former Paris Saint-Germain, Chelsea and Bayern Munich coach Tuchel is taking charge of his first game having been appointed last October and beginning his 18-month contract in January.
England: Jordan Pickford, Kyle Walker, Myles Lewis-Skelly, Dan Burn, Ezri Konsa, Declan Rice, Jude Bellingham, Curtis Jones, Marcus Rashford, Phil Foden, Harry Kane.