The 20-year-old pair of Johan Bakayoko and Aster Vranckx have been promoted from the under-21 squad, the Belgian football association said on Monday, for the Group F games against Austria in Brussels on Saturday and away to Estonia on June 20.
It is a second call-up for PSV Eindhoven striker Bakayoko but a first for Vranckx, who plays for AC Milan.
De Bruyne, who would have captained the team in the Group F encounters, tore his hamstring in Manchester City’s victory over Inter Milan in Istanbul on Saturday.