Harris has been enduring an eye injury leading up to the regular season after being injured in a fireworks incident on July 4th.
"He says he's ready, and he looks ready to go," said head coach Jim Harbaugh. "Those are really hard to predict, play counts and things of that nature. Get in there, play football, and have at it. That's kind of the mindset. Not kind of, that is the mindset."
The 27-year-old will continue to wear the visor he's been wearing since the start of the Chargers' camp.
Harris signed a one-year, $5.25 million deal with the Chargers during the offseason. His new deal includes a $3.75 million signing bonus with a $1.5 million base salary for the year. Harris can make up to an additional $4 million, depending on rushing yard incentives.
Harbaugh noted that Harris and rookie running back Omarion Hampton will be splitting carries against the Chiefs, but wouldn't get into the specifics of who will see more snaps.
After being selected 24th overall in the 2021 NFL Draft, Harris went on to put up four-straight 1,000-yard seasons with the Steelers before he hit free agency. In all of his four years, Harris has not missed a game - starting all 17 in each season.