It will be the 12th time Royal Lytham & St Annes has hosted the Championship. The course most recently welcomed the tournament in 2012, when South Africa's Ernie Els lifted the second Claret Jug of his career.
"Royal Lytham & St Annes is widely renowned as one of the world's finest links courses and has witnessed many great championship moments since The Open was first played there in 1926, when the legendary Bobby Jones won," Mark Darbon, Chief Executive of The R&A, said in a statement.
"This is one of golf's most cherished and historic venues, and The Open's return to these famous links will spark huge interest among fans to be part of one of the world's great sporting events and celebrate the rich traditions of golf's original Championship"
R&A officials met with US President Donald Trump's son Eric last year to discuss the possibility of The Open returning to Turnberry, Darbon said at the time.
Trump bought the property in 2014.
Turnberry, a seaside course in South Ayrshire, Scotland, has staged The Open four times - most recently in 2009 when American Stewart Cink won.
However, logistical problems mean The Open won't return there until the local transport infrastructure improves.
The 2026 Open will be played at Royal Birkdale Golf Club from July 16th-19th and returns to St Andrews in 2027.
Last year's Open was won by American Scottie Scheffler.