Red Bull driver Verstappen has already competed in several sports car races and has previous experience on the Nurburgring Nordschleife track.
The Dutch 28-year-old will share driving duties with Austrian Lucas Auer, Andorran Jules Gounon and Spaniard Daniel Juncadella in a Mercedes-AMG Team Verstappen Racing car carrying his familiar F1 number three.
Mercedes AMG Motorsport said Verstappen would also take part in a preparation race at the Nuerburgring on March 21 after it was rescheduled to ensure he could participate between F1 races in China and Japan.
The 24 Hours of Nuerburgring on May 16th-17th falls between the Miami Grand Prix on May 3rd and the Canadian Grand Prix in Montreal on May 24th.
The race, held annually since 1970, combines the famed and fearsome Nordschleife layout - known as the 'Green Hell' when it hosted Formula One in the 1960s and 70s - with the more modern grand prix circuit in a 25km loop.
Verstappen and teammates will share the car in separate stints at the wheel.
"The Nurburgring is a special place. There’s no other track like it. The 24h Nürburgring is a race that’s been on my bucket list for a long time, so I’m really thrilled we can make it happen now," said Verstappen in a statement.
"Last year, I was able to get my DMSB Permit Nordschleife and participate in NLS9, that we won. That preparation is very valuable, as we have learned a lot that we can take into our programme this year with NLS2 and the 24-hour race."
Verstappen has been critical of Formula 1's new cars and engines and said in pre-season testing he would be seeking fun in other series and forms of racing.