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England v Ireland, Sunday, 1:10am
Read our full preview of England v Ireland here.
England are outright second favourites to lift the trophy but have a long way to go to catch up to the French. The least they could do is atone for last week's shock Calcutta Cup loss to Scotland with what would be a tenth consecutive home victory, extending a run that started in the last week of the autumn 2024 with a 59-14 thrashing of Japan.
The home side are also unbeaten in Six Nations rugby at Twickenham since 2023 (W6) following their Round 1 thrashing of Wales and have been scoring freely of late, which should assist them in bucking the trend of scoring only 15-24 points in each of their last four home games against Ireland.
This is probably the worst Irish side to head to Twickenham in that period, which is why England are -10.5 point favourites, and if they cover that it's likely because they'll be keeping the Ireland attack frustrated.
Ireland have just 34 points to their name in this Six Nations series so far, and with England near impenetrable after half-time in their last three Six Nations home games, we're expecting Ireland to find points tough to come by.
Tip: Ireland to NOT reach 20 points - 1.80 @ Bet365
Bet explanation: We need Ireland to register a score between 0-19 points.
Wales v Scotland, Sunday, 3:40am
Read our full preview of Wales v Scotland here.
Wales continues to sink to new lows and they already find themselves having conceded more than 100 points in the first two rounds of the season, but this could be a match that they had earmarked at the start of the season as one where they could make a statement.
They've played two thrilling Six Nations fixtures against Scotland in the last two editions but on both occasions found themselves chasing enormous deficits only to fall agonisingly short. They had to come back from 35-8 down in Edinburgh (2025) and 27-0 in Cardiff (2024) only to lose by six points and one point respectively.
Those slow starts continue to follow them around the continent: only in one of Wales' last ten matches have they had a half-time lead, and they come into a game against a Scotland side that raced out of the blocks to a 24-10 half-time lead against England and does the bulk of their scoring before half-time.
Scotland scored 67% of their tries in the first half during the 2024 Six Nations, 69% in 2025 and so far 67% this year. We're expecting them to put a big lead on Wales in the first 40 minutes.
Tip: Scotland -8.5 point first half handicap - 1.90 @ Bet365
Bet explanation: Scotland needs to be leading by at least nine points at the half-time break.
France v Italy, Monday, 2:10am
Read our full preview of France v Italy here.
There are some very interesting handicaps on betting sites for the third and final match of the weekend, where France are expected to defeat Italy by about 29 points and go 3-0 heading into the rest week.
France slammed 73 points past Italy in this fixture last year but the two teams fought out a couple of exciting Six Nations contests before that - a 13-13 draw in Paris and 29-24 win to Les Bleus in Rome - and Italy's defending has been on point this season, even though they were able to score just one try through Giacomo Nicotera in last weekend's loss to Ireland.
Both of Italy's games this season produced just 33 total points, and what gives us confidence to take the 'unders' here is the impressive defensive resolve they showed over a full 80 minutes, conceding just 15 second half points against Ireland and eight against Scotland.
If they can put in another 80 minute shift here, they could avoid a significant blowout to the total.
Tip: Under 58.5 total points - 1.90 @ Bet365
Bet explanation: France and Italy need to combine for 0-58 total points in the match.
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Odds correct at the time of writing, subject to change.