Osayi-Samuel and Sofyan Amrabat are suspende while Dominik Livakovic, Jayden Oosterwolde, Rodrigo Becao and Mert Müldür are all out injured.
Diego Carlos, Anderson Talisca and Milan Skriniar have been added to the squad during the transfer window but they aren't elligible to play for Fenerbahce in the tournament.
Coach Jose Mourinho will also have to watch from the stands as he is also suspended for the match.
"We are in trouble at this moment to qualify," Mourinho with Fenerbahce in 22nd position while FC Midtjylland are in 19th spot. "Nine points may or may not be enough. It's still in our hands but right now in Europe, it's difficult for us because we are short of players."
"The only thing I know is that we have to go to Midtjylland and we have to fight for a result to qualify," he explained. We will go with 11 players, I don't think we will have many more.
"We don't have right-backs, we don't have left-backs, we don't have midfielders but we will have 11 guys fighting for the result and I'm hopeful that we can do it."
"We cannot be waiting for a combination of other results, we have to go for our result and we will."
Fenerbahce are currently second in the Turkish top-flight behind champions Galatasaray, who are ninth in the Europa League table.