Mbeumo notched two goals and an assist for the Bees, who impressed under the London sunshine en route to three points at the Gtech Community Stadium.
The 25-year-old got the scoring underway with a clinical right-footed finish before netting his second goal of the day - and 18th of the season - after half-time with a curler with his left.
Mbeumo turned provider for Yoane Wissa when he teed up the Congolese forward, who scored via a heavy deflection.
Mbeumo and Brentford next travel to take on third-placed Nottingham Forest on Sunday, May 1st.