Spurs have not won on their travels to West Ham since November 2019 and will be looking to right that, particularly following a limp 1-0 defeat at home to Bournemouth before the international break.
Levy departure unexpected
Saturday evening's match at the London Stadium will be Tottenham's first since the departure of chairman Daniel Levy, who stepped down after nearly 25 years last week.
On Levy's exit, Frank admitted: "I would say I don't think anyone expected it, but a decision is made and we move forward.
"He deserves huge praise. One of the longest-serving chairmen in the Premier League ever. He has laid the foundations for the future in terms of the world-class training centre and stadium.
"I have spoken him. It has been brief. I said thank you. I can only appreciate that in every aspect. I wish him all the best going forward."
Simons and Kolo Muani poised for debuts, Solanke out
Next, Frank gave an update on the fitness of summer recruits Xavi Simons and Randal Kolo Muani, with the pair "in contention" to make their Spurs debuts.
"Both of them are looking good. Both are in contention for the squad.
"Xavi, for natural reasons, is further down the line as he has played for Holland and a few games for Leipzig.
"Randal hasn't played since the Club World Cup and didn't really train at PSG, so he is not as fit as Xavi."
On how he plans to utilise them, Frank said: "I have some ideas. It is still a team I'm learning (about). It's one thing to look from the outside, it's another to feel them.
"Xavi, I see him as mainly a 10 or a left-sided player. Kolo I see as a striker or can play on either wing."
There was, however, less good news regarding Dominic Solanke, with the striker set to miss a second straight game with an ankle problem.
"Dom won't be available still. I don't expect it to be too long, but he won't be available for this game.
"I think right now we are doing everything we can in the medical team to get on top of it, and that's what we're focusing on. I get a feeling he is not too far away, but he's just fallen short for this week."
West Ham will 'raise their level'
West Ham suffered two heavy defeats to open their league campaign but rebounded with a resounding 3-0 win at Nottingham Forest before the pause, and Frank is anticipating a similarly tough match-up.
"I'm very excited. I know it means a lot to the fans. We will go there and do everything we can to win the game. We're facing a West Ham team that may not have had the best start, but they got a really good result at Nottingham (Forest).
"I have a big respect for Graham Potter and his staff. I know the game against West Ham will be extremely difficult. They will raise their level, but we will be ready for it."
'Difficult' Champions League squad selection
Frank also commented on the squad he selected for the league phase of the Champions League, with a notable omission being French forward Mathys Tel.
"That was an extremely difficult decision. I also think in many ways it was a bit unfair. The UEFA lists are not big enough. The load is getting more and more (on the players). We need a bigger squad. I can't understand why we need to limit ourselves.
"I like the idea of club-trained players by the way. I needed to name it before I really knew Matty (Mathys Tel). I think the way he handled it was extremely mature. It was really impressive."