Serbia's Miomir Kecmanovic piled up 14 aces with no double faults to knock out Italy's Luciano Darderi, the No. 3 seed, by a 4-6, 6-2, 6-3 count. Marcos Giron defeated No. 4 seed Brandon Nakashima 7-6 (7), 6-1 by saving five of six break points.
No. 2 seed Lorenzo Musetti of Italy outfought Switzerland's Stan Wawrinka 4-6, 7-6 (5), 6-4 while France's Alexandre Muller, the No. 5 seed, and Argentina's Tomas Martin Etcheverry battled through three tiebreakers before Muller emerged with the 6-7 (2), 7-6 (4), 7-6 (3) win. Germany's Yannick Hanfmann defeated Czech Republic's Vit Kopriva 6-2, 5-7, 7-5.
Moselle Open
Lucky loser Vitaliy Sachko of Ukraine continued his unlikely run in Metz, France, with a 7-5, 3-6, 7-5 second-round triumph over No. 3 seed Alexander Bublik of Kazakhstan. Bublik started the Moselle Open ranked 13th in the world while Sachko sat at No. 222.
France's Clement Tabur and Belgium's Alexander Blockx needed 2:51 to power through three tiebreakers before Tabur claimed the 6-7 (4), 7-6 (6), 7-6 (6) victory.
The other four singles matches needed just two sets. Learner Tien, Italy's Matteo Berrettini, Germany's Daniel Altmaier and France's Kyrian Jacquet advanced to Thursday's quarterfinals.