Rangers 5-4 Flyers
Artemi Panarin (13) scored two goals in the first two periods for the Rangers, but a four-goal second period for Philly put them up 4-2 heading into the third.
New York would rally behind a goal from Vincent Trocheck (6) and one on the power play from Mika Zibanejad (12) with under three minutes to go to send it into overtime.
After a scoreless OT, Trocheck would score once more during the shootout before Panarin would prove clutch and win the game for the boys in blue.
The Rangers improved to 18-15-4, while the Flyers fell to 17-10-7.
Red Wings 5-2 Capitals
The Red Wings would come out of the tunnel firing on all cylinders, scoring four straight goals in the first two periods.
Rookie John Leonard, brother of Capitals' forward Ryan Leonard, scored his first career NHL goal to get things started.
Aliaksei Protas (12) and Martin Fehervary (3) would cut the lead in half for the Caps to make it 4-2, but Detroit's star Dylan Larkin (18) sent home an empty-netter as Detroit improved to 20-13-3.
They jumped Washington in the Eastern Conference standings as the Caps fell to 19-12-4.
Senators 6-4 Blackhawks
Both teams exchanged three goals each through the first two periods before the Senators started to pull away in the final frame.
David Perron (7) would score two goals for Ottawa at the start of the third, one on a power play, to give them a commanding 5-3 lead.
Rookie Nick Lardis scored his first career NHL goal to cut the lead to one, but Fabian Zetterlund (7) would help the Sens bury the Blackhawks with one final goal as they moved on to their third-straight win.
Ottawa improved to 17-13-4, Chicago fell to 13-16-6 and have lost five straight.
Wild 5-2 Oilers
Connor McDavid (22) and Andrew Mangiapane (5) tied it up for the Oilers 2-2, both assisted by Leon Draisaitl (33), after Minnesota's Matthew Boldy (22) scored the first two goals of the game.
But Edmonton couldn't hang on as Minnesota scored three straight goals to put it out of reach.
The Wild are now undefeated (4-0) since trading for Quinn Hughes and are currently riding an NHL-best seven-game win streak. They improved to 22-9-5 on the season.
As for Edmonton, they fell to 17-13-6 on the year.
Sabres 3-2 Islanders
After Rasmus Dahlin (4) and Tage Thompson (18) got the Sabres out to a 2-0 lead, the Islanders rallied back to eventually send it to overtime.
Mathew Barzal (10) scored the first to cut the lead in half before the end of the second, while Emil Heineman (12) scored on the power play with just 29 seconds left in regulation to tie it up.
Despite going 4-on-3 during OT with a power play, the Islanders couldn't find the net, eventually losing during the shootout.
Barzal scored for New York in the shootout, but a pair of goals from Jack Quinn and Josh Norris helped the Sabres improve to 16-14-4.
Buffalo are now on a five-game win streak, while the Islanders fell to 19-13-4.
Blues 6-2 Panthers
Florida's Sam Reinhart (19) scored again for the Panthers, making it four total in the past three games, but it wasn't enough as the Blues poured it on.
Jake Neighbours (10) and Robert Thomas (9) both scored twice for the Blues as they improved to 14-15-8.
Jonatan Berggren (4) and Justin Faulk (9) scored the other two for St. Louis.
Florida fell to 19-14-2.
Canucks 5-4 Bruins
Linus Karlsson (7) scored twice for the Canucks, while Liam Ohgren (2) scored twice (with the game-winner during the shootout).
After both teams rallied from different deficits, Andrew Peeke (3) scored the one that sent it into overtime to keep the Bruins alive.
But after a scoreless OT, the Canucks hung on for the win thanks to Ohgren scoring the only goal of both teams in the shootout.
Vancouver, once at the bottom of the entire league, leaped up to just four points out of the second wild card spot as they ride a four-game win streak and improved to 15-17-3.
The Bruins dropped back-to-back games and their third loss in the last four games as they fell to 20-15-1.
Canadiens 4-0 Penguins
Montreal goalie Jacob Fowler earned his first career shutout in just his fourth start after stopping all 31 of the Penguins' shots.
He became the youngest goalie (21) in Canadiens history since Carey Price (20) in 2008 to record a shutout.
Josh Anderson (8) scored twice for the Habs, one short-handed and the other an empty net, while Juraj Slafkovský (10) scored on a power play.
Owen Beck scored his first career NHL goal, joining Detroit's John Leonard and Chicago's Nick Lardis, who also did the same tonight.
Montreal has now won back-to-back games as they improved to 19-12-4.
Pittsburgh dropped their third in a row as they fell to 14-11-9.
Lighting 6-4 Hurricanes
Despite the Canes getting out a 3-0 lead in the first period, Tampa Bay would go on to three straight in the second period and six of the game's last seven goal to complete the rally.
Jake Guentzel (17) led the way with two goals, while Dominic James put up two assists as the Lightning improved to 19-13-3.
After winning their previous five games, the Canes have now lost back-to-back as they fell to 22-10-3 on the season.
Predators 5-2 Maple Leafs
Down 2-1, the Predators rallied with three straight goals to take the lead, one of them coming from two-year man Adam Wilsby, who scored his first of the season and second of his career.
Bobby McMann (9) would cut the lead to 4-3 for the Lightning, but an empty-netter from Cole Smith (4) sealed the deal.
Nashville improved to 14-16-4. Toronto fell to 15-14-5.